Adult acute respiratory distress syndrome

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74Active trials79Specialists8Treatment centers

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Overview

Adult acute respiratory distress syndrome (ARDS) is a serious and life-threatening lung condition where the lungs become severely inflamed and fill with fluid. This makes it very hard for oxygen to pass from the air sacs in the lungs into the bloodstream. ARDS is also sometimes called acute lung injury or 'shock lung.' It is not a disease you are born with — it develops suddenly, usually as a complication of another serious illness or injury. ARDS can be triggered by many things, including severe pneumonia, sepsis (a dangerous body-wide infection), major trauma, inhaling harmful substances, or nearly drowning. When the lungs are injured, they become leaky and stiff, making breathing extremely difficult. Most people with ARDS need to be treated in an intensive care unit (ICU) and require a breathing machine (ventilator) to help them breathe. The main symptoms include severe shortness of breath, low oxygen levels in the blood, rapid breathing, and confusion. Treatment focuses on supporting the body while the lungs heal, using careful ventilator settings, positioning patients face-down (prone positioning), and treating the underlying cause. Some patients recover fully, but others may have lasting lung problems or other complications. Early recognition and expert ICU care are critical to improving survival.

Also known as:

Key symptoms:

Severe shortness of breath that comes on quicklyVery low oxygen levels in the bloodRapid, labored breathingFeeling of not being able to get enough airConfusion or disorientation due to low oxygenBlue-tinged lips or fingertips (cyanosis)Extreme fatigue and weaknessCrackling sounds in the lungs heard by a doctorChest tightness or painInability to breathe without a ventilator in severe cases

Clinical phenotype terms (17)— hover any for plain English
Abnormal circulating interleukin concentrationHP:0011117Abnormal blood gas levelHP:0012415Abnormality of tumor necrosis factor secretionHP:0011118Increased circulating interleukin 6 concentrationHP:0030783ShockHP:0031273Pulmonary edemaHP:0100598Diabetic ketoacidosisHP:0001953
Inheritance

Sporadic

Usually appears on its own, not inherited from a parent

Age of Onset

Adult

Begins in adulthood (age 18 or older)

Orphanet ↗NORD ↗

FDA & Trial Timeline

10 events
Sep 2026Spontaneous vs Controlled Mechanical Ventilation in Acute Hypoxemic Respiratory Failure

Oslo University Hospital — NA

TrialNOT YET RECRUITING
Aug 2026Fostamatinib for Treating Acute Respiratory Distress Syndrome (ARDS) in Hospitalized Adults

Inova Health Care Services — PHASE2

TrialNOT YET RECRUITING
Aug 2026Assessment of Acute Respiratory Distress in Children Presenting to the Emergency Department: Clinical, Epidemiological, and Etiological Insights

Assiut University

TrialNOT YET RECRUITING
May 2026Recovery of Physical Function After Critical Illness In Older Adults

University of Kentucky

TrialNOT YET RECRUITING
Apr 2026Study of Nogapendekin Alfa Inbakicept and iNKT Cells in Critically Ill Adults With Severe Community-Acquired Pneumonia

ImmunityBio, Inc. — PHASE3

TrialNOT YET RECRUITING
Apr 2026Nogapendekin Alfa-Inbakicept and iNKT Cells for Critically Ill Adults With Severe Community-Acquired Pneumonia (With or Without Sepsis/ARDS)

ImmunityBio, Inc. — PHASE2

TrialNOT YET RECRUITING
Mar 2026Clinical Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of HT31-1 for Treating ARDS

HTIC, Inc — PHASE1

TrialNOT YET RECRUITING
Mar 2026Machine Learning Prediction of Mortality After Prone Positioning in ARDS

Shanghai Zhongshan Hospital

TrialNOT YET RECRUITING
Mar 2026Relationship Between the Level of Positive End-expiratory Pressure and Venous Congestion During Acute Respiratory Distress Syndrome.

University Hospital, Angers

TrialNOT YET RECRUITING
Feb 2026HemodynamIc eFfects of Lung Collapse and overdIstension During ARDS

Fondazione Policlinico Universitario Agostino Gemelli IRCCS — NA

TrialNOT YET RECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

No FDA-approved treatments are currently listed for Adult acute respiratory distress syndrome.

20 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.

View clinical trials →

Clinical Trials

20 recruitingView all trials with filters →
Other20 trials
EIT Assessment of Overdistension in ARDS Patients in Prone Position
Actively Recruiting
· Sites: Bayonne; Pessac · Age: 1899 yrs
The Physiological Effect of RCexp on Ventilation/Perfusion Distribution
Actively Recruiting
· Sites: Nanjing, Jiangsu · Age: 1999 yrs
Turning Ratios Into Prognosis: Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Powerful Predictors of ARDS in Pediatric Burn Patients: A Prospective Evaluation
Actively Recruiting
· Sites: Cairo · Age: 112 yrs
Effectiveness of Low Volume and Low Pressure in Severe Hypoxemic Patients
Active
· Sites: Ranica, BG · Age: 1899 yrs
Evaluating the Safety and Performance of the MiniLung Petite Kit in Neonatal and Pediatric Patients With Acute Respiratory and Cardiac Failure
Actively Recruiting
PI: Andreas Müller, Prof. Dr. (University Hospital, Bonn) · Sites: Bonn, North Rhine-Westphalia; Mannheim
Molecular Epidemiology of Acute Respiratory Distress Syndrome (ARDS)
Active
PI: David Christiani, MD (Harvard University School of Public Health) · Sites: Boston, Massachusetts · Age: 1880 yrs
Safety of Low PEEP Maneuvers During ARDS Management
Actively Recruiting
· Sites: Amiens · Age: 1899 yrs
Physiological Studies in the Prone Position in Patients With ARDS
Actively Recruiting
· Sites: Chengdu, Sichuan · Age: 1890 yrs
AEROSOL THERAPY IN ARDS PATIENTS (AERO-IN-ARDS)
Actively Recruiting
PI: Mohan Gurjjar, MD (SGPGIMS) · Sites: Lucknow, Uttar Pradesh · Age: 1899 yrs
PRactice of VENTilation in Critically Ill PEDiatric Patients
Actively Recruiting
PI: Martin CJ Kneyber, MD PhD (University Medical Center Groningen) · Sites: Groningen · Age: 018 yrs
Effect of Transpulmonary MP on Prognosis of Patients With Severe ARDS Treated With VV-ECMO
Actively Recruiting
PI: Rui Wang, Dr. (Beijing Chao-Yang Hospital, Capital Medical Univer) · Sites: Beijing, Beijing Municipality · Age: 1875 yrs
Reverse Trigger Phenotypification and Response to Ventilatory Adjustments
Actively Recruiting
PI: Miguel Ibarra Estrada, MD (Hospital Civil Fray Antonio Alcalde) · Sites: Guadalajara · Age: 1890 yrs
The ICU LIBERATION Study
Actively Recruiting
· Sites: Tokyo · Age: 1699 yrs
Practices of Prone Positioning Ventilation in Patients With Moderate-to-Severe ARDS in Intensive Care Units: A Registry-Based Observational Study
Actively Recruiting
· Sites: Nanjing, Jiangsu · Age: 1899 yrs
NMR Based Metabolomics Kinetics in ARDS Patients
Actively Recruiting
PI: Neeraj Sinha, M.Sc., Ph.D. (Centre of Biomedical Research) · Sites: Lucknow, Uttar Pradesh · Age: 1865 yrs
Cardiac Magnetic Resonance Tissue Characterization in COVID-19 Survivors
Actively Recruiting
PI: Jiwon Kim, MD (Weill Medical College of Cornell University) · Sites: Brooklyn, New York; New York, New York +1 more · Age: 1899 yrs
CytOSorb TreatMent Of Critically Ill PatientS Registry
Actively Recruiting
PI: Ricard Ferrer Roca, MD (Hospital Vall d'Hebron) · Sites: Klagenfurt; Vienna +26 more
SerpinB3 Expression, PAR2 and SCCA-PD Polymorphism in Acute Respiratory Distress Syndrome
Actively Recruiting
· Sites: Padua, PD · Age: 1899 yrs
The APS Phenotyping Study
Actively Recruiting
PI: Wesley H. Self, MD, MPH (Vanderbilt University Medical Center) · Sites: Fresno, California; Palo Alto, California +18 more · Age: 1899 yrs
Evaluation of Physical Capacity and Energy Requirements in Patients With Hypoxemic Acute Respiratory Failure
Active
· Sites: L'Hospitalet de Llobregat, Barcelona · Age: 1899 yrs

Specialists

Showing 25 of 79View all specialists →
SP
Spyros D Mentzelopoulos, MD, PhD
Specialist
PI on 3 active trials
CM
Christopher G Hughes, M.D.
Specialist
PI on 1 active trial
VF
Vasileios Zochios, MRCP FFICM
Specialist
PI on 1 active trial
SP
Shirley Lima Campos, PhD
Specialist
PI on 1 active trial
PE
Prashant Nasa, MD EDIC
Specialist
PI on 1 active trial
HL
Hui Lin
Specialist
1 Adult acute respiratory distress syndrome publication
NY
Nadir Yehya
PHILADELPHIA, PA
Specialist
1 Adult acute respiratory distress syndrome publication
LC
Li Chen
Specialist
1 Adult acute respiratory distress syndrome publication
HW
Haopeng Wu
Specialist
1 Adult acute respiratory distress syndrome publication
RS
Raghavendra R Sanivarapu
MIDLAND, TX
Specialist
1 Adult acute respiratory distress syndrome publication
FS
Fen Sheng
Specialist
1 Adult acute respiratory distress syndrome publication
LS
Lincoln S Smith
MYRTLE BEACH, SC
Specialist
1 Adult acute respiratory distress syndrome publication
BP
Bhavesh M Patel
Specialist
1 Adult acute respiratory distress syndrome publication
UO
Usama Osman
Specialist
1 Adult acute respiratory distress syndrome publication
RK
Robinder G Khemani
LOS ANGELES, CA
Specialist
1 Adult acute respiratory distress syndrome publication
AB
Anoopindar K Bhalla
LOS ANGELES, CA
Specialist
1 Adult acute respiratory distress syndrome publication
DM
Davide Chiumello, MD
Specialist
PI on 2 active trials
JM
Jolanta Airey, MD
Specialist
PI on 2 active trials
BP
Bodil Steen Rasmussen, MD, PhD
Specialist
PI on 2 active trials
SM
Stephen M Standage, MD
CINCINNATI, OH
Specialist
PI on 1 active trial
JP
Jean-Damien Ricard, MD, PhD
Specialist
PI on 5 active trials
LP
Luca Sangiorgi, MD, Phd
Specialist
PI on 1 active trial
MH
Michael O Harhay
Specialist
1 Adult acute respiratory distress syndrome publication
NM
Nuala J Meyer
PHILADELPHIA, PA
Specialist
1 Adult acute respiratory distress syndrome publication

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Adult acute respiratory distress syndrome.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about Adult acute respiratory distress syndrome

Disease timeline:

New recruiting trial: Inhaled Dornase Alpha to Reduce Respiratory Failure After Severe Trauma

A new clinical trial is recruiting patients for Adult acute respiratory distress syndrome

New recruiting trial: Effects on Biotrauma of NMBAs and PP Association During ARDS

A new clinical trial is recruiting patients for Adult acute respiratory distress syndrome

New recruiting trial: The Efficacy of P0.1-guided Sedation Protocol in Critically Ill Patients Receiving Invasive Mechanical Ventilation: A Randomized Controlled Trial

A new clinical trial is recruiting patients for Adult acute respiratory distress syndrome

New recruiting trial: The Role of Elastic Power in Predicting the Severity and Mortality in Adult Patients With ARDS Due to Pneumonia

A new clinical trial is recruiting patients for Adult acute respiratory distress syndrome

New recruiting trial: Trial of Therapeutic Hypothermia in Patients With ARDS

A new clinical trial is recruiting patients for Adult acute respiratory distress syndrome

New recruiting trial: The Effects of Music Therapy on Adult Patients Requiring Mechanical Ventilation in the ICU

A new clinical trial is recruiting patients for Adult acute respiratory distress syndrome

New recruiting trial: Interest of Hypnosis When Setting up Non-invasive Ventilation in a Conscious Patient With COPD and/or Obesity With a BMI Greater Than 30, Suffering Fromacute Respiratory Distress in Adult Intensive Care

A new clinical trial is recruiting patients for Adult acute respiratory distress syndrome

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Questions for your doctor

Bring these to your next appointment

  • Q1.What caused my ARDS, and has that underlying cause been fully treated?,What are my expected lung function and recovery timeline?,Do I need pulmonary rehabilitation, and how do I access it?,What symptoms should prompt me to seek emergency care after discharge?,Are there any long-term medications or oxygen therapy I will need at home?,What mental health support is available for ARDS survivors?,When is it safe to return to work or resume physical activities?

Common questions about Adult acute respiratory distress syndrome

What is Adult acute respiratory distress syndrome?

Adult acute respiratory distress syndrome (ARDS) is a serious and life-threatening lung condition where the lungs become severely inflamed and fill with fluid. This makes it very hard for oxygen to pass from the air sacs in the lungs into the bloodstream. ARDS is also sometimes called acute lung injury or 'shock lung.' It is not a disease you are born with — it develops suddenly, usually as a complication of another serious illness or injury. ARDS can be triggered by many things, including severe pneumonia, sepsis (a dangerous body-wide infection), major trauma, inhaling harmful substances, o

How is Adult acute respiratory distress syndrome inherited?

Adult acute respiratory distress syndrome follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.

At what age does Adult acute respiratory distress syndrome typically begin?

Typical onset of Adult acute respiratory distress syndrome is adult. Age of onset can vary across affected individuals.

Are there clinical trials for Adult acute respiratory distress syndrome?

Yes — 20 recruiting clinical trials are currently listed for Adult acute respiratory distress syndrome on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Adult acute respiratory distress syndrome?

25 specialists and care centers treating Adult acute respiratory distress syndrome are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.