Overview
Adult acute respiratory distress syndrome (ARDS) is a serious and life-threatening lung condition where the lungs become severely inflamed and fill with fluid. This makes it very hard for oxygen to pass from the air sacs in the lungs into the bloodstream. ARDS is also sometimes called acute lung injury or 'shock lung.' It is not a disease you are born with — it develops suddenly, usually as a complication of another serious illness or injury. ARDS can be triggered by many things, including severe pneumonia, sepsis (a dangerous body-wide infection), major trauma, inhaling harmful substances, or nearly drowning. When the lungs are injured, they become leaky and stiff, making breathing extremely difficult. Most people with ARDS need to be treated in an intensive care unit (ICU) and require a breathing machine (ventilator) to help them breathe. The main symptoms include severe shortness of breath, low oxygen levels in the blood, rapid breathing, and confusion. Treatment focuses on supporting the body while the lungs heal, using careful ventilator settings, positioning patients face-down (prone positioning), and treating the underlying cause. Some patients recover fully, but others may have lasting lung problems or other complications. Early recognition and expert ICU care are critical to improving survival.
Also known as:
Key symptoms:
Severe shortness of breath that comes on quicklyVery low oxygen levels in the bloodRapid, labored breathingFeeling of not being able to get enough airConfusion or disorientation due to low oxygenBlue-tinged lips or fingertips (cyanosis)Extreme fatigue and weaknessCrackling sounds in the lungs heard by a doctorChest tightness or painInability to breathe without a ventilator in severe cases
Clinical phenotype terms (17)— hover any for plain English
Sporadic
Usually appears on its own, not inherited from a parent
Adult
Begins in adulthood (age 18 or older)
FDA & Trial Timeline
10 eventsOslo University Hospital — NA
Inova Health Care Services — PHASE2
Assiut University
University of Kentucky
ImmunityBio, Inc. — PHASE3
ImmunityBio, Inc. — PHASE2
HTIC, Inc — PHASE1
Shanghai Zhongshan Hospital
University Hospital, Angers
Fondazione Policlinico Universitario Agostino Gemelli IRCCS — NA
Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.
Treatments
No FDA-approved treatments are currently listed for Adult acute respiratory distress syndrome.
20 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.
View clinical trials →Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Adult acute respiratory distress syndrome.
Community
No community posts yet. Be the first to share your experience with Adult acute respiratory distress syndrome.
Start the conversation →Latest news about Adult acute respiratory distress syndrome
Disease timeline:
New recruiting trial: Inhaled Dornase Alpha to Reduce Respiratory Failure After Severe Trauma
A new clinical trial is recruiting patients for Adult acute respiratory distress syndrome
New recruiting trial: Effects on Biotrauma of NMBAs and PP Association During ARDS
A new clinical trial is recruiting patients for Adult acute respiratory distress syndrome
New recruiting trial: The Efficacy of P0.1-guided Sedation Protocol in Critically Ill Patients Receiving Invasive Mechanical Ventilation: A Randomized Controlled Trial
A new clinical trial is recruiting patients for Adult acute respiratory distress syndrome
New recruiting trial: The Role of Elastic Power in Predicting the Severity and Mortality in Adult Patients With ARDS Due to Pneumonia
A new clinical trial is recruiting patients for Adult acute respiratory distress syndrome
New recruiting trial: Trial of Therapeutic Hypothermia in Patients With ARDS
A new clinical trial is recruiting patients for Adult acute respiratory distress syndrome
New recruiting trial: The Effects of Music Therapy on Adult Patients Requiring Mechanical Ventilation in the ICU
A new clinical trial is recruiting patients for Adult acute respiratory distress syndrome
New recruiting trial: Interest of Hypnosis When Setting up Non-invasive Ventilation in a Conscious Patient With COPD and/or Obesity With a BMI Greater Than 30, Suffering Fromacute Respiratory Distress in Adult Intensive Care
A new clinical trial is recruiting patients for Adult acute respiratory distress syndrome
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What caused my ARDS, and has that underlying cause been fully treated?,What are my expected lung function and recovery timeline?,Do I need pulmonary rehabilitation, and how do I access it?,What symptoms should prompt me to seek emergency care after discharge?,Are there any long-term medications or oxygen therapy I will need at home?,What mental health support is available for ARDS survivors?,When is it safe to return to work or resume physical activities?
Common questions about Adult acute respiratory distress syndrome
What is Adult acute respiratory distress syndrome?
Adult acute respiratory distress syndrome (ARDS) is a serious and life-threatening lung condition where the lungs become severely inflamed and fill with fluid. This makes it very hard for oxygen to pass from the air sacs in the lungs into the bloodstream. ARDS is also sometimes called acute lung injury or 'shock lung.' It is not a disease you are born with — it develops suddenly, usually as a complication of another serious illness or injury. ARDS can be triggered by many things, including severe pneumonia, sepsis (a dangerous body-wide infection), major trauma, inhaling harmful substances, o
How is Adult acute respiratory distress syndrome inherited?
Adult acute respiratory distress syndrome follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does Adult acute respiratory distress syndrome typically begin?
Typical onset of Adult acute respiratory distress syndrome is adult. Age of onset can vary across affected individuals.
Are there clinical trials for Adult acute respiratory distress syndrome?
Yes — 20 recruiting clinical trials are currently listed for Adult acute respiratory distress syndrome on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.
Which specialists treat Adult acute respiratory distress syndrome?
25 specialists and care centers treating Adult acute respiratory distress syndrome are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.