Acute zonal occult outer retinopathy

Acute Zonal Occult Outer Retinopathy, commonly known as AZOOR, is a rare eye condition that affects the outer layer of the retina — the light-sensitive tissue at the back of the eye. In AZOOR, one or more zones of the outer retina stop working properly, leading to blind spots and other vision changes. The condition most often affects young to middle-aged women, and it typically starts in one eye, though it can eventually involve both eyes. Patients usually notice the sudden appearance of blind spots (scotomas) in their field of vision, along with flashing lights (photopsia). Some people also experience a general dimming of vision or changes in how they see colors. The condition can be alarming because symptoms often come on quickly. In many cases, the visual loss stabilizes over time, but some patients experience progressive worsening. The exact cause of AZOOR is not fully understood. It is thought to involve an autoimmune or inflammatory process that damages the photoreceptor cells in the outer retina. There is currently no proven cure or standard treatment for AZOOR. Some doctors have tried corticosteroids or other immunosuppressive medications to reduce inflammation, but results have been mixed. Management focuses on monitoring vision changes and providing supportive care. Research is ongoing to better understand the disease and develop effective therapies.

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Bring these to your next appointment

• Q1.How much of my retina is currently affected, and is the disease active or stable?,What tests will you use to monitor my condition over time, and how often should I be seen?,Are there any treatments you would recommend trying in my specific case?,What are the chances that my other eye will also be affected?,Should I be referred to a low vision rehabilitation specialist?,Are there any clinical trials or research studies I could participate in?,What symptoms should prompt me to seek urgent care between appointments?

Common questions about Acute zonal occult outer retinopathy