Von Hippel-Lindau disease

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At a Glance

Live from database

Regulatory Watchboard

10 events
Mar 2026Extension Study for Participants in Studies That Include Belzutifan (MK-6482-043/LITESPARK-043)

Merck Sharp & Dohme LLC — PHASE3

TrialRECRUITING
Feb 2026CAT-VHL Exploring the Role of Carbonic Anhydrase IX as Diagnostic and Theranostic Target in Von-Hippel Lindau Disease

IRCCS Ospedale San Raffaele — PHASE2

TrialRECRUITING
Feb 2026Quality of Life, Psychological Impact, and Care-related Challenges in Patients Affected by Von Hippel-Lindau Syndrome.

IRCCS Ospedale San Raffaele

TrialNOT YET RECRUITING
Jul 2024Promoting Stress Management and Resilience Among Individuals With Von Hippel- Lindau Disease

Massachusetts General Hospital — NA

TrialENROLLING BY INVITATION
Jul 2024A Study of HS-10516 in Patients With VHL Syndrome Associated Tumors

Jiangsu Hansoh Pharmaceutical Co., Ltd. — PHASE1

TrialRECRUITING
Jan 2024Real-World Effectiveness and Pharmacogenetics of Belzutifan in VHL Syndrome: The BELIEVE-VHL Trial

José Claudio Casali da Rocha — PHASE2

TrialRECRUITING
Aug 2023Data Collection Protocol for Patients With Von Hippel Lindau Disease

M.D. Anderson Cancer Center

TrialRECRUITING
Jun 2023Mechanisms of Somatic Mutation and Tumor Initiation in Pre-malignant Kidney Tubule Cells

IRCCS San Raffaele

TrialRECRUITING
Jan 2023Propranolol and Von Hippel-Lindau Disease

Assistance Publique - Hôpitaux de Paris — NA

TrialRECRUITING
Aug 2021Welireg: FDA approved

Treatment of adult patients with von Hippel-Lindau (VHL) disease who require therapy for associated renal cell carcinoma (RCC), central nervous system (CNS) hemangioblastomas, or pancreatic neuroendocrine tumors (pNET), not requiring immediate surgery

FDAcompleted

Data from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Financial Assistance

1 program

FINANCIAL LANDSCAPE SUMMARY

1

Total programs

1

Open now

Patient Assistance Programs1

Welireg

Merck Sharp & Dohme LLC

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Approved Treatments

1 FDA-approved

Welireg

(BELZUTIFAN)Orphan drug

Merck Sharp & Dohme LLC

Hypoxia-inducible Factor Inhibitor [EPC]

12.1 Mechanism of Action Belzutifan is an inhibitor of hypoxia-inducible factor 2 alpha (HIF-2α). HIF-2α is a transcription factor that plays a role i...

Approved Aug 2021FDA label ↗

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Clinical Trial Landscape

16 active trials
1Phase 3
5Phase 2
3N/A
7Unknown
16Total recruiting
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Recent News & Research

No recent news articles indexed yet for Von Hippel-Lindau disease.
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Specialist Network

Top 6 by expertise

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