T-cell prolymphocytic leukemia

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At a Glance

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Regulatory Watchboard

10 events
Jun 2026Phase Ib/II Trial of Cladribine/Ruxolitinib/Venetoclax in Patients With Relapsed/Refractory T-cell Prolymphocytic Leukemia

M.D. Anderson Cancer Center — PHASE1, PHASE2

TrialNOT YET RECRUITING
Apr 2026KESIMPTA: New indication approved
FDAcompleted
Feb 2026VENCLEXTA: New indication approved
FDAcompleted
Aug 2025KESIMPTA: New indication approved
FDAcompleted
May 2025Duvelisib and Venetoclax in Patients With Relapsed or Refractory Peripheral T-cell Lymphoma (PTCL)

Jonsson Comprehensive Cancer Center — PHASE1, PHASE2

TrialRECRUITING
Apr 2025Intravenous Autologous CD19 CAR-T Cells for R/ R MM, B-ALL, and B-Cell Lymphoma

Anhui Provincial Hospital — NA

TrialRECRUITING
Apr 2024KESIMPTA: New indication approved
FDAcompleted
Feb 2024CD19-targeted CAR T Cell Autotransfusion for the Treatment of Recurrent/Refractory B-cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma in Children With CD19+

Zhu Xiaofan — NA

TrialRECRUITING
Jan 2024KESIMPTA: New indication approved
FDAcompleted
Jul 2023Study of TBI-2001(Autologous CD19 Specific Chimeric Antigen Receptor (CAR) Gene-transduced T Lymphocytes) for Relapsed or Refractory CD19+ B-cell Lymphoma, CLL/SLL

University Health Network, Toronto — PHASE1

TrialRECRUITING

Data from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Financial Assistance

5 programs

FINANCIAL LANDSCAPE SUMMARY

5

Total programs

5

Open now

2

Copay cards

Copay Assistance2

Rituxan SC

Genentech, Inc.

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Fludara

Berlex Laboratories, Inc.

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Patient Assistance Programs3

GAZYVA

Genentech Inc., a member of the Roche Group

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VENCLEXTA

AbbVie, Inc

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Campath

Genzyme Corporation

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Approved Treatments

8 FDA-approved

BRUKINSA

(zanubrutinib)Orphan drug

BeOne Medicines USA, Inc.

Kinase Inhibitor [EPC]

12.1 Mechanism of Action Zanubrutinib is a small-molecule inhibitor of Bruton's tyrosine kinase (BTK). Zanubrutinib forms a covalent bond with a cyste...

Approved Jan 2023FDA label ↗

Rituxan SC

(rituximab and recombinant human hyaluronidase)Orphan drug

Genentech, Inc.

Approved Jun 2017

Bendeka

(bendamustine for 50 ml admixture)Orphan drug

Eagle Pharmaceuticals, Inc.

12.1 Mechanism of Action Bendamustine is a bifunctional mechlorethamine derivative containing a purine-like benzimidazole ring. Mechlorethamine and it...

Approved Dec 2015FDA label ↗

ARZERRA

(ofatumumab)Orphan drug

Novartis Pharmaceuticals Corporation

CD20-directed Cytolytic Antibody [EPC]

12.1 Mechanism of Action Ofatumumab binds specifically to both the small and large extracellular loops of the CD20 molecule. The CD20 molecule is expr...

Approved Oct 2009FDA label ↗

Treanda

(Bendamustine hydrochloride)Orphan drug

Cephalon, Inc.

12.1 Mechanism of Action Bendamustine is a bifunctional mechlorethamine derivative containing a purine-like benzimidazole ring. Mechlorethamine and it...

Approved Mar 2008FDA label ↗

Campath

(alemtuzumab)Orphan drug

Genzyme Corporation

CD52-directed Cytolytic Antibody [EPC]

12.1 Mechanism of Action CAMPATH binds to CD52, an antigen present on the surface of B and T lymphocytes, a majority of monocytes, macrophages, NK cel...

Approved May 2001FDA label ↗

Fludara

(Fludarabine phosphate)Orphan drug

Berlex Laboratories, Inc.

12.1 Mechanism of Action Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine ...

Approved Apr 1991FDA label ↗

Zydelig

(idelalisib)Orphan drugstandard

Gilead Sciences, Inc.

Kinase Inhibitor [EPC]

12.1 Mechanism of Action Idelalisib is an inhibitor of phosphatidylinositol 3-kinase, PI3Kδ, which is expressed in normal and malignant B-cells. Idela...

FDA label ↗

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Clinical Trial Landscape

6 active trials
4Phase 1
1Unknown
1PHASE1, PHASE2
6Total recruiting
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Recent News & Research

6 articles
Annals of hematologyApr 12, 2026

A case of T-prolymphocytic leukemia harboring RAS mutation.

The text reports the clinical case of a 61-year-old woman with a long history of generalized pruritus who was eventually diagnosed with T-cell prolymphocytic leukemia (T-PLL), a rare and aggressive T-...

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Leukemia & lymphomaApr 6, 2026

Allogeneic transplant outcomes in T-cell prolymphocytic leukemia: a single-center retrospective study.

T-cell prolymphocytic leukemia (T-PLL) is a rare and aggressive malignancy with a poor prognosis. Allogeneic hematopoietic stem cell transplantation (HCT) is often used for treatment, but its effectiv...

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CancersMar 28, 2026

How We Evaluate and Treat Leukemic Presentations of Mature T-Cell Lymphomas.

T-cell non-Hodgkin lymphomas, which arise from post-thymic mature T cells, constitute approximately 10-15% of all non-Hodgkin lymphomas. Their leukemic presentations, referred to here as mature T-cell...

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Journal of cutaneous pathologyMar 9, 2026

Cutaneous-Only Relapse in T-Cell Prolymphocytic Leukemia With JAK2 Rearrangement.

Cutaneous-Only Relapse in T-Cell Prolymphocytic Leukemia With JAK2 Rearrangement.

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International journal of laboratory hematologyMar 3, 2026

Splenic B-Cell Lymphoma/Leukemia With TCL1 Gene Rearrangement.

Splenic B-cell lymphoma/leukemia includes a group of indolent small B-cell lymphomas/leukemias that share overlapping morphological and immunophenotypic features, making accurate diagnosis challenging...

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Journal of hematologyMar 2, 2026

A Rare Presentation of T-cell Prolymphocytic Leukemia With Abnormal Uterine Bleeding.

T-cell prolymphocytic leukemia (T-PLL) is a rare and clinically aggressive T-cell neoplasm, which is composed of lymphoid cells that are of post-thymic T-cell origin. This is a case of a 57-year-old f...

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Specialist Network

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