Primary hyperoxaluria type 1

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At a Glance

Live from database

Regulatory Watchboard

4 events
Dec 2024Oxalate Excretion Profile in Patients with a Heterozygous Mutation of the AGXT (alanine-glyoxylate Aminotransferase) Gene

Hospices Civils de Lyon — NA

TrialRECRUITING
Aug 2024Evaluation of the Efficacy and Safety of Stiripentol in Patients 6 Years and Older With Primary Hyperoxaluria Type 1, 2 or 3

Biocodex — PHASE3

TrialNOT YET RECRUITING
Nov 2020Oxlumo: FDA approved

treatment of primary hyperoxaluria type 1 (PH1) to lower urinary oxalate levels in pediatric and adult patients

FDAcompleted
Jul 2019Long Term Extension Study in Patients With Primary Hyperoxaluria

Dicerna Pharmaceuticals, Inc., a Novo Nordisk company — PHASE3

TrialACTIVE NOT RECRUITING

Data from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Financial Assistance

2 programs

FINANCIAL LANDSCAPE SUMMARY

2

Total programs

2

Open now

Patient Assistance Programs2

Oxlumo

Alnylam Pharmaceuticals, Inc.

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Rivfloza

Novo Nordisk

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Approved Treatments

2 FDA-approved

Oxlumo

(LUMASIRAN)Orphan drug

Alnylam Pharmaceuticals, Inc.

12.1 Mechanism of Action Lumasiran reduces levels of glycolate oxidase (GO) enzyme by targeting the hydroxyacid oxidase 1 ( HAO1 ) messenger ribonucle...

Approved Nov 2020FDA label ↗

Rivfloza

(NEDOSIRAN)Orphan drugstandard

Novo Nordisk

12.1 Mechanism of Action Nedosiran is a double-stranded siRNA, conjugated to GalNAc aminosugar residues. After subcutaneous administration, the GalNAc...

FDA label ↗

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Clinical Trial Landscape

1 active trial
1Phase 3
1Total recruiting
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Recent News & Research

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Specialist Network

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