Paroxysmal nocturnal hemoglobinuria

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At a Glance

Live from database

Regulatory Watchboard

10 events
Jul 2026A Study of Iptacopan in Korean Patients With Paroxysmal Nocturnal Hemoglobinuria or C3 Glomerulopathy

Novartis Pharmaceuticals

TrialNOT YET RECRUITING
Jun 2026A Long-term Efficacy and Safety of NTQ5082 Capsules

Nanjing Chia-tai Tianqing Pharmaceutical — PHASE3

TrialNOT YET RECRUITING
Jun 2026Study of NM8074 in Soliris-Treated Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)

NovelMed Therapeutics — PHASE2

TrialNOT YET RECRUITING
Apr 2026Study of Efficacy and Safety of NM8074 in Adult PNH Patients Who Are Naive to Complement Inhibitor Therapy

NovelMed Therapeutics — PHASE2

TrialNOT YET RECRUITING
Mar 2026Danicopan PMS in Korea

AstraZeneca

TrialNOT YET RECRUITING
Mar 2026A Study to Evaluate How Pozelimab + Cemdisiran Combination Therapy Works in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Whose Current Treatment is Not Working Efficiently

Regeneron Pharmaceuticals — PHASE3

TrialRECRUITING
Mar 2026BKEMV: New indication approved
FDAcompleted
Mar 2026A Phase I Clinical Trial to Evaluate CMS-D017 Following Single and Multiple Doses in Healthy Participants

Shenzhen Kangzhe Biotechnology Co., Ltd. — PHASE1

TrialNOT YET RECRUITING
Feb 2026Study of Safety and Efficacy of HS-10542 in Patients With Paroxysmal Nocturnal Hemoglobinuria

Jiangsu Hansoh Pharmaceutical Co., Ltd. — PHASE1, PHASE2

TrialRECRUITING
Feb 2026A First-in-Human Safety and Efficacy Study of ALN-CFB, a Small Interfering RNA (siRNA) Targeting Complement Factor B, in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria With Persistent Anemia on a C5 Inhibitor

Regeneron Pharmaceuticals — PHASE1, PHASE2

TrialRECRUITING

Data from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Financial Assistance

20 programs

FINANCIAL LANDSCAPE SUMMARY

20

Total programs

12

Open now

2

Foundation grants

7

Copay cards

11

Travel grants

Foundation Grants2

PAN Foundation — Paroxysmal nocturnal hemoglobinuria

PAN Foundation

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HealthWell Foundation — Paroxysmal nocturnal hemoglobinuria

HealthWell Foundation

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Copay Assistance7

BKEMV

Amgen

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FABHALTA

Novartis

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Empaveli

Apellis

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Voydeya

Alexion

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SOLIRIS

Alexion

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Ultomiris

Alexion

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Piasky

Genentech

OpenContact for detailsApply ↗

Travel Grants11

Alexion Access Navigator - SOLIRIS Access and Reimbursement Guide

Alexion

Contact for detailsApply ↗

Alexion OneSource - Navigating Insurance for SOLIRIS Patient Guide

Alexion OneSource

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Alexion OneSource program (via National Kidney Foundation)

Contact for detailsApply ↗

PAN Foundation - Paroxysmal Nocturnal Hemoglobinuria Fund

PAN Foundation

ClosedContact for detailsApply ↗

PAN Foundation Paroxysmal Nocturnal Hemoglobinuria Financial Assistance

PAN Foundation

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PAN Foundation Paroxysmal Nocturnal Hemoglobinuria Fund

PAN Foundation

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Paroxysmal Nocturnal Hemoglobinuria Financial Assistance Program

The Assistance Fund

Contact for detailsApply ↗

PNH Patient Travel Assistance Fund

Aplastic Anemia and MDS International Foundation (AAMDSIF)

Contact for detailsApply ↗

The Assistance Fund (TAF) - Paroxysmal Nocturnal Hemoglobinuria Financial Assistance

The Assistance Fund (TAF)

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The Assistance Fund Paroxysmal Nocturnal Hemoglobinuria Financial Assistance Program

The Assistance Fund

Contact for detailsApply ↗

ULTOMIRIS Savings and Affordability

Contact for detailsApply ↗

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Approved Treatments

8 FDA-approved

FABHALTA

(IPTACOPAN)Orphan drug

Novartis Pharmaceuticals Corporation

Approved Dec 2023FDA label ↗

BKEMV

(ECULIZUMAB-AEEB)Orphan drug

Amgen Inc

FDA label ↗

Ultomiris

(RAVULIZUMAB)Orphan drug

Alexion Pharmaceuticals Inc.

FDA label ↗

Voydeya

(DANICOPAN)Orphan drug

Alexion Pharmaceuticals Inc.

FDA label ↗

SOLIRIS

(ECULIZUMAB)Orphan drug

Alexion Pharmaceuticals Inc.

FDA label ↗

EPYSQLI

(ECULIZUMAB-AAGH)Orphan drug

Teva Pharmaceuticals USA, Inc.

FDA label ↗

Piasky

(CROVALIMAB)Orphan drug

Genentech, Inc.

FDA label ↗

Empaveli

(PEGCETACOPLAN)Orphan drug

Apellis Pharmaceuticals, Inc.

FDA label ↗

View full treatment details on disease page →

Clinical Trial Landscape

39 active trials
12Phase 3
8Phase 2
2Phase 1
3N/A
9Unknown
1PHASE2, PHASE3
4PHASE1, PHASE2
39Total recruiting
Search clinical trials for Paroxysmal nocturnal hemoglobinuria

Recent News & Research

6 articles
LeukemiaApr 22, 2026

Imputing causality and clonal dynamics from single-cell transcriptomics in paroxysmal nocturnal hemoglobinuria.

Paroxysmal nocturnal hemoglobinuria (PNH) originates from hematopoietic stem cells (HSCs) harboring somatic mutations in the phosphatidylinositol glycan class A (PIGA) gene. Clonal expansion of PIGA-m...

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NefrologiaApr 17, 2026

Complement blockade: Therapeutic promises and remaining challenges in clinical practice.

Understanding of the complement system in glomerulopathies has advanced significantly, revealing that this system-beyond its role in innate immunity-is a key mediator of kidney injury across a wide sp...

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PloS oneApr 16, 2026

Epidemiology and care management of Paroxysmal Nocturnal Hemoglobinuria (PNH) in a real-world setting in France: Description from the French National Hospitalization Database.

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired stem-cell disease causing anemia, aplasia and thromboses, affecting ~1/80,000 patients in France. Treatment mainly involves C5 inhibitors ...

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Blood advancesApr 15, 2026

Ravulizumab for Treatment of Paroxysmal Nocturnal Hemoglobinuria During Pregnancy.

Ravulizumab, a humanized, long-acting monoclonal antibody against complement factor C5, is a widely utilized treatment for paroxysmal nocturnal hemoglobinuria (PNH). As pregnant women with PNH are at ...

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Annals of African medicineApr 7, 2026

Acute Pancreatitis as a Therapeutic Complication in Case of Paroxysmal Nocturnal Hemoglobinuria.

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired hematopoietic disorder requiring careful therapeutic management. In resource-limited settings, traditional treatments may carry significant...

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Hematology (Amsterdam, Netherlands)Mar 20, 2026

Case report: persistent anemia after eculizumab in paroxysmal nocturnal hemoglobinuria: non-dominantly active intravascular hemolysis.

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare condition characterized by intravascular hemolysis (IVH), thrombosis, and organ damage. Although C5 complement inhibitors such as eculizumab have si...

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