Myelodysplastic neoplasm with increased blasts

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At a Glance

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Regulatory Watchboard

10 events
Dec 2025Luspatercept + Darbepoetin in MDS

Yale University — PHASE2

TrialRECRUITING
Oct 2025Safety and Feasibility of Sulforaphane to Promote Early Haematopoietic Recovery After Cord Blood Transplantation

Institute of Hematology & Blood Diseases Hospital, China — NA

TrialRECRUITING
Sep 2025Evaluation of Treosulfan Versus Melphalan Conditioning Followed by PTCy in Patients With AML and MDS Undergoing Allogeneic Transplantation

Technische Universität Dresden — PHASE2

TrialNOT YET RECRUITING
Jan 2025A Phase Ib Study of Rezatapopt in Combination With Azacitidine in Patients With TP53Y220C Mutant Myeloid Malignancies (Acute Myeloid Leukemia or Myelodysplastic Syndrome)

M.D. Anderson Cancer Center — PHASE1

TrialRECRUITING
Jan 2024Preemptive CIML NK Cell Therapy After Hematopoietic Stem Cell Transplantation

Dana-Farber Cancer Institute — PHASE1

TrialRECRUITING
Aug 2023Treosulfan-Based Versus Clofarabine-Based Conditioning Before Donor Hematopoietic Stem Cell Transplant for the Treatment of Myelodysplastic Syndromes or Acute Myeloid Leukemia

Fred Hutchinson Cancer Center — PHASE2

TrialACTIVE NOT RECRUITING
Dec 2021Repurposing Metformin As a Leukemia-preventive Drug in CCUS and LR-MDS

Kirsten Grønbæk — PHASE2

TrialRECRUITING
Dec 2021Anti-NKG2A Monoclonal Antibody for AML or MDS Patients Undergoing Haploidentical Transplantation

Istituto Clinico Humanitas — PHASE2

TrialRECRUITING
Oct 2020ATG Plus PTCy vs ATG for CGVHD Prophylaxis

McMaster University — PHASE2

TrialACTIVE NOT RECRUITING
Jul 2020A Phase Ib Study of APG-115 Single Agent or in Combination With Azacitidine or Cytarabine in Patients With AML and MDS.

Ascentage Pharma Group Inc. — PHASE1

TrialRECRUITING

Data from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Financial Assistance

FINANCIAL LANDSCAPE SUMMARY

0

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No financial assistance programs currently listed for Myelodysplastic neoplasm with increased blasts.
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Approved Treatments

2 FDA-approved

Azacitidine

(AZACITIDINE)Orphan drugstandard

Dr. Reddy's Laboratories Inc.

Nucleoside Metabolic Inhibitor [EPC]

12.1 Mechanism of Action Azacitidine for injection is a pyrimidine nucleoside analog of cytidine. Azacitidine for injection is believed to exert its a...

FDA label ↗

Azacitidine

(AZACITIDINE FOR)Orphan drugstandard

Pilnova Pharma Inc

Nucleoside Metabolic Inhibitor [EPC]

12.1 Mechanism of Action Azacitidine is a pyrimidine nucleoside analog of cytidine. Azacitidine is believed to exert its antineoplastic effects by cau...

FDA label ↗

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Clinical Trial Landscape

11 active trials
1Phase 3
3Phase 2
5Phase 1
1Unknown
1PHASE1, PHASE2
11Total recruiting
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