Idiopathic hypersomnia

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At a Glance

Live from database

Regulatory Watchboard

10 events
Jun 2026Effects of Operational Naps on Blood Pressure and Performance Among Night Shift Workers

University of Pittsburgh — NA

TrialNOT YET RECRUITING
Mar 2026A Phase 3 Efficacy and Safety Study of HBS-301 in Participants With Idiopathic Hypersomnia (IH)

Harmony Biosciences Management, Inc. — PHASE3

TrialRECRUITING
Feb 2026Association Between Slow Wave Activity and Sleep Inertia

Mahidol University

TrialNOT YET RECRUITING
Nov 2025Study of Sleep Inertia in Major Depressive Disorder by the Psychomotor Vigilance Task

Centre Hospitalier Universitaire de Nīmes

TrialRECRUITING
Nov 2025Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia

Nyree Penn — PHASE1

TrialNOT YET RECRUITING
Oct 2025Effect of Low Sodium Oxybate (LXB) on Autonomic Symptom Burden in Idiopathic Hypersomnia Patients With Postural Tachycardia Syndrome

Stanford University — PHASE4

TrialNOT YET RECRUITING
Aug 2025A Long-term Extension Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia

Centessa Pharmaceuticals (UK) Limited — PHASE2

TrialRECRUITING
Jun 2025A Novel Approach to Manage Symptoms of Narcolepsy and Idiopathic Hypersomnia

University of Sydney — NA

TrialRECRUITING
May 2025A Study to Evaluate the Safety and Effectiveness of ALKS 2680 in Subjects With Idiopathic Hypersomnia

Alkermes, Inc. — PHASE2

TrialRECRUITING
Feb 2025A Study of TAK-360 in Adults With Idiopathic Hypersomnia

Takeda — PHASE2

TrialRECRUITING

Data from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Financial Assistance

2 programs

FINANCIAL LANDSCAPE SUMMARY

2

Total programs

2

Open now

Patient Assistance Programs2

WAKIX

Harmony Biosciences Management, Inc.

OpenContact for details

Provigil

Cephalon, Inc.

OpenContact for details

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Approved Treatments

4 FDA-approved

Provigil

(Modafinil)Orphan drug

Cephalon, Inc.

Sympathomimetic-like Agent [EPC]

12.1 Mechanism of Action The mechanism(s) through which modafinil promotes wakefulness is unknown. Modafinil has wake-promoting actions similar to sym...

Approved Dec 1998FDA label ↗

Lumryz

(sodium oxybate)Orphan drugstandard

Flamel Ireland Limited dba Avadel Ireland

FDA label ↗

Omeprazole

(OMEPRAZOLE)Orphan drugstandard

PD-Rx Pharmaceuticals, Inc.

Proton Pump Inhibitor [EPC]

12.1 Mechanism of Action Omeprazole belongs to a class of antisecretory compounds, the substituted benzimidazoles, that suppress gastric acid secretio...

FDA label ↗

Xywav

(calcium, magnesium, potassium, and sodium oxybates)Orphan drugstandard

Jazz Pharmaceuticals Ireland Limited

12.1 Mechanism of Action XYWAV is a CNS depressant. The exact mechanism of action of XYWAV in the treatment of narcolepsy and idiopathic hypersomnia i...

FDA label ↗

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Clinical Trial Landscape

16 active trials
2Phase 3
1Phase 4
4Phase 2
4N/A
4Unknown
1PHASE2, PHASE3
16Total recruiting
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Recent News & Research

6 articles
BREAKINGFDA

FDA Approves CABERGOLINE

CABERGOLINE (CABERGOLINE) received FDA approval.

Read ↗
SleepApr 16, 2026

Sleep time and SOREMPs features support idiopathic hypersomnia and narcolepsy type 2 as a single disease entity.

Idiopathic hypersomnia (IH) and narcolepsy type 2 (NT2) are rare hypersomnolence disorders with unknown pathophysiology. Recent evidence suggests they may belong to the same spectrum. This study compa...

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SleepApr 16, 2026

Perspectives on idiopathic hypersomnia: diagnostic challenges, unknown pathophysiological, and emerging therapeutic strategies.

Idiopathic hypersomnia is a rare chronic neurological condition that may be characterized by excessive daytime sleepiness, and/or prolonged nocturnal sleep, and also sleep inertia, yet its underlying ...

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Journal of sleep researchMar 20, 2026

Age at Onset and Delays in Diagnosis of Central Disorders of Hypersomnolence Over the Past 30 Years.

Patients with narcolepsy type 1 (NT1), type 2 (NT2), idiopathic hypersomnia (IH) usually suffer from symptoms for years, even decades, before being diagnosed. We aimed to assess age at onset, age at d...

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Journal of sleep researchMar 20, 2026

Dynamic Functional Network Connectivity Patterns Distinguish Neurobiological Substrates of Narcolepsy Type 1 and Idiopathic Hypersomnia: Potential Biomarkers From Resting-State fMRI.

This study aimed to explore dynamic functional network connectivity (dFNC) differences between narcolepsy type 1 (NT1), idiopathic hypersomnia (IH), and healthy controls (HCs), and evaluate the potent...

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Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep MedicineMar 19, 2026

Correction to: Clinical and polysomnographic changes in idiopathic hypersomnia ten years after the diagnosis.

Correction to: Clinical and polysomnographic changes in idiopathic hypersomnia ten years after the diagnosis.

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Specialist Network

Top 6 by expertise

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