Constitutional mismatch repair deficiency syndrome

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At a Glance

Live from database

Regulatory Watchboard

10 events
Mar 2026Immunotherapy for Surgery Avoidance in Vulnerable dMMR Endometrial Cancer

Women's Hospital School Of Medicine Zhejiang University — PHASE2

TrialNOT YET RECRUITING
Jan 2026Factors Influencing Immunotherapy Response in dMMR/MSI-H Gastric/Gastroesophageal Junction Adenocarcinoma

Shanghai Zhongshan Hospital — PHASE2

TrialNOT YET RECRUITING
Sep 2025Immunotherapy (Toripalimab) for Reducing Recurrence Risk After Surgery for Mismatch Repair Deficient Stage IIB, IIC, or III Colon Cancer

Emory University — PHASE2

TrialRECRUITING
Feb 2025Pembrolizumab With Olaparib as Combined Therapy in Metastatic Pancreatic Cancer

Cambridge University Hospitals NHS Foundation Trust — PHASE2

TrialRECRUITING
Jan 2024Liquid Biopsy and Machine Learning for Early Colorectal Cancer, Adenomas, Lynch Cancers, and Residual Disease Detection

San Raffaele University

TrialRECRUITING
Jan 2024Neoadjuvant Immunotherapy for T4 dMMR Colon Cancer

Peking Union Medical College Hospital — NA

TrialRECRUITING
Jun 2023Study of HRO761 Alone or in Combination in Cancer Patients With Specific DNA Alterations Called Microsatellite Instability or Mismatch Repair Deficiency.

Novartis Pharmaceuticals — PHASE1

TrialACTIVE NOT RECRUITING
May 2023Perioperative Chemotherapy Plus Toripalimab for dMMR Locally Advanced Gastric or Esophagogastric Junction Adenocarcinoma

Yu jiren — PHASE2

TrialRECRUITING
Sep 2022T-regulatory Cell Depletion with E7777 Combined with Pembrolizumab in Recurrent or Metastatic Solid Tumors

Alexander B Olawaiye, MD — PHASE1, PHASE2

TrialRECRUITING
Mar 2021Evaluation of the Reliability of the Determination of MisMatch Repair Deficiency Status by Endoscopic Biopsies in Oesophagus and Gastric Adenocarcinoma.

Assistance Publique - Hôpitaux de Paris — NA

TrialNOT YET RECRUITING

Data from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Financial Assistance

1 program

FINANCIAL LANDSCAPE SUMMARY

1

Total programs

1

Open now

Patient Assistance Programs1

Yervoy

Bristol-Myers Squibb Company

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Approved Treatments

1 FDA-approved

IMFINZI

(durvalumab)Orphan drugstandard

AstraZeneca Pharmaceuticals LP

Programmed Death Ligand-1 Blocker [EPC]

12.1 Mechanism of Action Expression of programmed cell death ligand-1 (PD-L1) can be induced by inflammatory signals (e.g., IFN-gamma) and can be expr...

FDA label ↗

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Clinical Trial Landscape

5 active trials
2Phase 2
1Phase 1
1N/A
1Unknown
5Total recruiting
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Recent News & Research

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Specialist Network

Top 6 by expertise

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