Complications after hematopoietic stem cell transplantation

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At a Glance

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Regulatory Watchboard

10 events
Apr 2026Respiratory Microbioma and Respiratory Complications After Hematopoietic Stem Cell Transplantion

University Hospital, Caen

TrialNOT YET RECRUITING
Mar 2026APHEXDA: New indication approved
FDAcompleted
Jan 2026Critical Illness After Hematopoietic Cell Transplantation

Peking University People's Hospital

TrialNOT YET RECRUITING
Dec 2025

Yartemlea: FDA approved

treatment of adult and pediatric patients 2 years of age and older with hematopoietic stem cell transplant-associated thrombotic microangiopathy (TA-TMA)

FDAcompleted
Oct 2024Comparison of Intralipid With SMOF Lipid Following HSCT

Shahid Beheshti University — NA

TrialRECRUITING
Aug 2024Moxibustion in the Treatment of Hemorrhagic Cystitis After Allo-HSCT

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology — NA

TrialRECRUITING
May 2024Efficacy and Safety of Avatrombopag in the Treatment of Thrombocytopenia After Haplo-HSCT

Peking University People's Hospital — PHASE2, PHASE3

TrialRECRUITING
Mar 2024Moxibustion for the Prevention of Hemorrhagic Cystitis After Allo-HSCT

Yi Zhang — NA

TrialRECRUITING
Mar 2024AlloLife - Life After Transplantation

University Hospital, Essen — NA

TrialNOT YET RECRUITING
Sep 2023High-Altitude Hematology Observation-Stem Cell Transplantation (HALO-SCT)

Yigeng Cao,MD,PhD — NA

TrialRECRUITING

Data from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Financial Assistance

4 programs

FINANCIAL LANDSCAPE SUMMARY

4

Total programs

4

Open now

Patient Assistance Programs4

Neupogen

Amgen, Inc.

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Defitelio

Jazz Pharmaceuticals, Inc.

OpenContact for detailsApply ↗

PREVYMIS

Merck Sharp & Dohme LLC

OpenContact for detailsApply ↗

Yartemlea

Omeros Corporation

OpenContact for details

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Approved Treatments

6 FDA-approved

Yartemlea

(narsoplimab-wuug)Orphan drug

Omeros Corporation

12.1 Mechanism of Action Narsoplimab-wuug inhibits MASP-2, the effector enzyme of the lectin pathway of the complement system, blocking lectin-depende...

Approved Dec 2025FDA label ↗

Grafapex

(TREOSULFAN)Orphan drug

Medexus Pharma, Inc.

Approved Jan 2025FDA label ↗

Aphexda

(motixafortide)Orphan drug

Ayrmid Pharma Ltd.

12.1 Mechanism of Action Motixafortide is an inhibitor of the C-X-C Motif Chemokine Receptor 4 (CXCR4) and blocks the binding of its cognate ligand, s...

Approved Sep 2023FDA label ↗

Defitelio

(defibrotide)Orphan drugstandard

Jazz Pharmaceuticals, Inc.

12.1 Mechanism of Action The mechanism of action of defibrotide sodium has not been fully elucidated. In vitro , defibrotide sodium enhances the enzym...

FDA label ↗

PREVYMIS

(letermovir)Orphan drugstandard

Merck Sharp & Dohme LLC

Cytomegalovirus DNA Terminase Complex Inhibitor [EPC]

12.1 Mechanism of Action PREVYMIS is an antiviral drug against CMV [see Microbiology (12.4) ] .

FDA label ↗

Leukine

(Sargramostim)Orphan drugstandard

Immunex Corporation

Leukocyte Growth Factor [EPC]

12.1 Mechanism of Action Sargramostim (GM-CSF) belongs to a group of growth factors termed colony-stimulating factors which support survival, clonal e...

FDA label ↗

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Clinical Trial Landscape

3 active trials
3N/A
3Total recruiting
Search clinical trials for Complications after hematopoietic stem cell transplantation

Recent News & Research

6 articles
Transplantation and cellular therapyApr 8, 2026

A Significant Risk Factor for Post-Transplant Lymphoproliferative Disorder in Pediatric Recipients: Low CD3+CD4+ T Cell Count at 30 Days after Hematopoietic Stem Cell Transplantation.

Post-transplant lymphoproliferative disorder (PTLD) is a potentially life-threatening complication that arises early after pediatric hematopoietic stem cell transplantation (HSCT), primarily due to po...

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Frontiers in medicineApr 6, 2026

Development and effectiveness evaluation of a mobile health-based follow-up management model for patients after hematopoietic stem cell transplantation.

To evaluate the association between mobile health (mHealth)-based follow-up and quality of life, self-management capacity, and complication control in patients after hematopoietic stem cell transplant...

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Transplantation and cellular therapyMar 29, 2026

Kidney and Blood Pressure Outcomes in Children Surviving at Least 6 Months after Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis.

Pediatric hematopoietic stem cell transplantation (HSCT) recipients are at risk of developing kidney and high blood pressure (BP) conditions, but the prevalence of these conditions is unclear. We aime...

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Hematology, transfusion and cell therapyMar 29, 2026

Mineral disorders after hematopoietic stem cell transplantation in patients receiving parenteral nutrition.

Parenteral nutrition is a critical therapeutic approach for patients undergoing hematopoietic stem cell transplantation. However, parenteral nutrition is associated with complications such as mineral ...

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Pediatric hematology and oncologyMar 15, 2026

Long-Term Health Outcomes in Male Survivors of Childhood Cancer After Hematopoietic Stem Cell Transplantation: A Registry-Based Study.

Late effects are a major concern after pediatric hematopoietic stem cell transplantation (HSCT), but data on health outcomes beyond early adulthood remain scarce. This study assessed long-term morbidi...

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PeerJMar 11, 2026

Risk factors for acute kidney injury after hematopoietic stem cell transplantation in children: a single-center retrospective study.

To analyze the clinical characteristics and risk factors of acute kidney injury (AKI) after hematopoietic stem cell transplantation (HCT) in children. The clinical data of children who underwent HCT a...

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