Chronic granulomatous disease

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At a Glance

Live from database

1FDA treatments

20Recruiting trials

Regulatory Watchboard

10 events

Mar 2026Hematopoietic Stem Cell Transplantation (HSCT) for Common Variable Immunodeficiency (CVID) and Other Autoimmune Manifestations of Primary Immune Regulatory Disorders (PIRD)

Paul Szabolcs — PHASE2

TrialRECRUITING

Sep 2025Part B- G1X-CGD (Lentiviral Vector Transduced CD34+ Cells) in Patients With X-Linked Chronic Granulomatous Disease

National Institute of Allergy and Infectious Diseases (NIAID) — PHASE1

TrialENROLLING BY INVITATION

Aug 2025Study of EN-374 Gene Therapy in Participants With X-Linked Chronic Granulomatous Disease

Ensoma — PHASE1, PHASE2

TrialRECRUITING

Nov 2024Prevalence of Antibodies and Cytokines in Participants With Chronic Granulomatous Disease

Ensoma

TrialRECRUITING

Oct 2024A Study of the Safety and Efficacy of Prime Editing (PM359) in Participants With p47phox Autosomal Recessive Chronic Granulomatous Disease (CGD )

Prime Medicine, Inc. — PHASE1, PHASE2

TrialACTIVE NOT RECRUITING

Jun 2024pCCLCHIM-p47 (Lentiviral Vector Transduced CD34 Plus Cells) in Patients With p47 Autosomal Recessive Chronic Granulomatous Disease (AR-CGD)

National Institute of Allergy and Infectious Diseases (NIAID) — PHASE1, PHASE2

TrialENROLLING BY INVITATION

Apr 2024Base Editing for Mutation Repair in Hematopoietic Stem & Progenitor Cells for X-Linked Chronic Granulomatous Disease

National Institute of Allergy and Infectious Diseases (NIAID) — PHASE1

TrialRECRUITING

Mar 2023Lentiviral Gene Therapy for p47 AR-CGD

Great Ormond Street Hospital for Children NHS Foundation Trust — PHASE1, PHASE2

TrialRECRUITING

Jan 2023Study to Assess the Use of JSP191 in Matched Unrelated Donor Transplantation for Chronic Granulomatous Disease (CGD)

National Institute of Allergy and Infectious Diseases (NIAID) — EARLY_PHASE1

TrialACTIVE NOT RECRUITING

Aug 2022Safety and Efficacy of Tofacitinib for Chronic Granulomatous Disease With Inflammatory Complications

National Institute of Allergy and Infectious Diseases (NIAID) — PHASE1, PHASE2

TrialENROLLING BY INVITATION

Data from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Financial Assistance

FINANCIAL LANDSCAPE SUMMARY

0

Total programs

No financial assistance programs currently listed for Chronic granulomatous disease.
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Approved Treatments

1 FDA-approved

Actimmune

(Interferon gamma 1-b)Orphan drug

Horizon Therapeutic Ireland DAC

Interferon gamma [EPC]

12.1 Mechanism of Action Interferons bind to specific cell surface receptors and initiate a sequence of intracellular events that lead to the transcri...

Approved Dec 1990FDA label ↗

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Clinical Trial Landscape

20 active trials

2Phase 2

3Phase 1

2N/A

2Unknown

2EARLY_PHASE1

9PHASE1, PHASE2

20Total recruiting

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Recent News & Research

No recent news articles indexed yet for Chronic granulomatous disease.
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Specialist Network

Top 6 by expertise

Donald B. Kohn, MD, D.D.S

University of California, Los Angeles

📍 NEW HAVEN, CT

Score 332 trials

Paul Szabolcs, MD

UPMC Children's Hospital of Pittsburgh

📍 Pittsburgh, Pennsylvania

Score 297 trials

Elizabeth M Kang, M.D.

National Institute of Allergy and Infectious Diseases (NIAID)

📍 Bethesda, Maryland

Score 1311 trials

Suk S De Ravin, M.D.

National Institute of Allergy and Infectious Diseases (NIAID)

📍 Bethesda, Maryland

Score 126 trials

Joanne Kurtzberg, MD, M.D

Duke University

📍 DURHAM, NC

Score 1111 trials

Harry L Malech, M.D.

National Institute of Allergy and Infectious Diseases (NIAID)

📍 Bethesda, Maryland

Score 52 trials

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