Blastic plasmacytoid dendritic cell neoplasm

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At a Glance

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Regulatory Watchboard

7 events
Dec 2025Phase II Study Evaluating the Efficacy and Safety of the Combination of Tagraxofusp and Venetoclax in Treatment-naive Blastic Plasmacytoid Dendritic Cell Neoplasm Patients

French Innovative Leukemia Organisation — PHASE2

TrialNOT YET RECRUITING
Aug 2023Safety and Efficacy of CD123-targeted CAR-NK for Relapsed/Refractory Acute Myeloid Leukemia or Blastic Plasmacytoid Dendritic Cell Neoplasm

Chongqing Precision Biotech Co., Ltd — PHASE1, PHASE2

TrialRECRUITING
Jul 2022Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) International Registry

Immune Oncology Research Institute

TrialRECRUITING
May 2020Venetoclax, SL-401, and Chemotherapy for the Treatment of Blastic Plasmacytoid Dendritic Cell Neoplasm

M.D. Anderson Cancer Center — PHASE2

TrialRECRUITING
Dec 2018

ELZONRIS: FDA approved

ELZONRIS is a CD123-directed cytotoxin for the treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN) in adults and in pediatric patients 2 years and older.

FDAcompleted
Jan 2018Study of IMGN632 in Patients With Untreated BPDCN and Relapsed/Refractory BPDCN

AbbVie — PHASE1, PHASE2

TrialACTIVE NOT RECRUITING
Jun 2017SL-401 in Combination With Azacitidine or Azacitidine/Venetoclax in Acute Myeloid Leukemia (AML), High-Risk Myelodysplastic Syndrome (MDS) or Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)

Dana-Farber Cancer Institute — PHASE1

TrialRECRUITING

Data from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Financial Assistance

1 program

FINANCIAL LANDSCAPE SUMMARY

1

Total programs

1

Open now

Patient Assistance Programs1

ELZONRIS

Stemline Therapeutics, Inc.

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Approved Treatments

1 FDA-approved

ELZONRIS

(Tagraxofusp-erzs)Orphan drug

Stemline Therapeutics, Inc.

CD123 Interaction [EPC]

12.1 Mechanism of Action Tagraxofusp-erzs is a CD123-directed cytotoxin composed of recombinant human interleukin-3 (IL-3) and truncated diphtheria to...

Approved Dec 2018FDA label ↗

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Clinical Trial Landscape

5 active trials
1Phase 2
1Phase 1
1Unknown
2PHASE1, PHASE2
5Total recruiting
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