Alpha-1-antitrypsin deficiency

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At a Glance

Live from database

Regulatory Watchboard

10 events
Apr 2026Phase 4, Double-blind Study Evaluating the Response on Computed Tomography (CT) Lung Density Decline Rates of Respreeza / Zemaira Weekly for 3 Years in Adults With alpha1 Antitrypsin Deficiency (AATD)

CSL Behring — PHASE4

TrialNOT YET RECRUITING
Feb 2026A Study of AIR-001 in Adults With Alpha-1 Antitrypsin Deficiency (AATD)

AIRNA Corporation — PHASE1

TrialRECRUITING
Jan 2026Prevalence of Alpha-1 Antitrypsin Deficiency in Non-Cirrhotic Liver Cancer

University Hospital, Bordeaux

TrialNOT YET RECRUITING
Dec 2025A Study of TSRA-196 in Adults With PiZZ Alpha-1 Antitrypsin Deficiency (AATD)

Tessera Therapeutics, Inc. — PHASE1, PHASE2

TrialNOT YET RECRUITING
Sep 2025Genetic Variation in IgG in Alpha 1 Antitrypsin Deficiency

University of Alabama at Birmingham — PHASE4

TrialRECRUITING
Aug 2025Screening for Alpha-1 Antitrypsin Deficiency in Patients With Airway Obstruction

Muğla Sıtkı Koçman University

TrialRECRUITING
Jun 2025Study of YOLT-202 in the Treatment of Alpha-1 Antitrypsin Deficiency (AATD)

RenJi Hospital — EARLY_PHASE1

TrialACTIVE NOT RECRUITING
May 2025PiMZ Longitudinal Cohort (PiMZ Logic)

Columbia University

TrialRECRUITING
Feb 2025Gene Therapy for Alpha 1- Antitrypsin Deficiency

Weill Medical College of Cornell University — PHASE1

TrialRECRUITING
Feb 2025Study of BMN 349 Single Dose in PiZZ and PiMZ/MASH Adult Participants

BioMarin Pharmaceutical — PHASE1

TrialRECRUITING

Data from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Financial Assistance

6 programs

FINANCIAL LANDSCAPE SUMMARY

6

Total programs

6

Open now

5

Foundation grants

1

Copay cards

Foundation Grants5

HealthWell Foundation — Alpha-1-antitrypsin deficiency

HealthWell Foundation

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NORD Patient Assistance — Alpha-1-antitrypsin deficiency

NORD Patient Assistance

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Patient Services Inc — Alpha-1-antitrypsin deficiency

Patient Services Inc

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PAN Foundation — Alpha-1-antitrypsin deficiency

PAN Foundation

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The Assistance Fund — Alpha-1-antitrypsin deficiency

The Assistance Fund

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Copay Assistance1

Prolastin

Bayer Corporation

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Approved Treatments

1 FDA-approved

Prolastin

(Alpha1-proteinase inhibitor (human))Orphan drug

Bayer Corporation

Approved Dec 1987

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Clinical Trial Landscape

27 active trials
6Phase 3
1Phase 4
1Phase 2
4Phase 1
3N/A
9Unknown
2PHASE1, PHASE2
1EARLY_PHASE1
27Total recruiting
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Recent News & Research

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Specialist Network

Top 6 by expertise

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