Acute promyelocytic leukemia

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At a Glance

Live from database

2FDA treatments

33Recruiting trials

Regulatory Watchboard

10 events

Mar 2026Venetoclax, Azacitidine, and Mitoxantrone Hydrochloride Liposome Versus Idarubicin and Cytarabine in Newly Diagnosed AML

The First Affiliated Hospital of Soochow University — PHASE3

TrialNOT YET RECRUITING

Mar 2026Pivotal Open-label Phase 3 Clinical Study of QTX-2101 in Adult Patients With Acute Promyelocytic Leukemia

Quetzal Therapeutics — PHASE3

TrialRECRUITING

Jan 2026A Trial to Investigate Whether Oral Arsenic Trioxide Is Similar to Intravenous Arsenic Trioxide in Pharmacokinetics, Safety, and Efficacy (LATITUDE/SDKARS-301)

SDK Therapeutics, Inc. — PHASE3

TrialNOT YET RECRUITING

Dec 2025Bleximenib in Combination With Standard Induction and Consolidation Therapy Followed by Maintenance for Treatment of Patients With Acute Myeloid Leukemia (AML)

Stichting Hemato-Oncologie voor Volwassenen Nederland — PHASE3

TrialNOT YET RECRUITING

Nov 2025Study of Revumenib in Combination With Intensive Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia (AML) With a NPM1 Mutation

Syndax Pharmaceuticals — PHASE3

TrialRECRUITING

Jul 2025Venetoclax Combined With ATRA and ATO in Hyperleukocytic Acute Promyelocytic Leukemia

Anhui Medical University — NA

TrialACTIVE NOT RECRUITING

Jun 2025A Study of Bleximenib, Venetoclax and Azacitidine For Treatment of Participants With Newly Diagnosed Acute Myeloid Leukemia (AML)

Janssen Research & Development, LLC — PHASE3

TrialRECRUITING

Jun 2025Early Use of Realgar-Indigo Naturalis Formula (RIF) Combined With All-trans Retinoic Acid (ATRA) for Treating Acute Promyelocytic Leukemia (APL).

First Affiliated Hospital Xi'an Jiaotong University — PHASE3

TrialRECRUITING

Jun 2025Efficacy of Gilteritinib in Combination With FLAI as Induction Therapy of FLT3-positive Acute Myeloid Leukemia

Gruppo Italiano Malattie EMatologiche dell'Adulto — PHASE2

TrialNOT YET RECRUITING

Mar 2025L-Annamycin for Injection in Combination With Cytarabine Injection as Second Line Therapy for Remission Induction in Adult Subjects With Refractory/Relapsed AML

Moleculin Biotech, Inc. — PHASE2, PHASE3

TrialRECRUITING

Data from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Financial Assistance

2 programs

FINANCIAL LANDSCAPE SUMMARY

2

Total programs

2

Open now

2

Copay cards

Copay Assistance2

Vesanoid

Hoffmann-La Roche, Inc.

OpenContact for detailsApply ↗

Trisenox

Teva

OpenContact for detailsApply ↗

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Approved Treatments

2 FDA-approved

Trisenox

(Arsenic trioxide)Orphan drug

Teva Branded Pharmaceutical Products R&D, Inc.

12.1 Mechanism of Action The mechanism of action of TRISENOX is not completely understood. Arsenic trioxide causes morphological changes and DNA fragm...

Approved Sep 2000FDA label ↗

Vesanoid

(Tretinoin)Orphan drug

Hoffmann-La Roche, Inc.

Retinoid [EPC]

12.1 Mechanism of Action Tretinoin induces cytodifferentiation and decreased proliferation of APL cells in culture and in vivo . In APL patients, tret...

Approved Nov 1995FDA label ↗

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Clinical Trial Landscape

33 active trials

11Phase 3

9Phase 2

2Phase 1

4N/A

4Unknown

2PHASE2, PHASE3

1PHASE1, PHASE2

33Total recruiting

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Recent News & Research

1 article

Clin Hematol IntJan 1, 2026

Leukemia cutis and all-trans retinoic acid-induced myocarditis in acute promyelocytic leukemia

Published in Clin Hematol Int. Rahbari KJ et al.

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Specialist Network

Top 6 by expertise

Eduardo M Rego, MD PhD

Instituto do Cancer do Estado de Sao Paulo

Score 371 trial

Global Clinical Leader

Daiichi Sankyo

Score 3644 trials4 pubs

Harry Gill, MD, DDS

The University of Hong Kong

📍 FRESNO, CA

Score 351 trial

Brenda Sandmaier

Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium

📍 SEATTLE, WA

Score 2917 trials

Xue-Qun Luo, professor

First Affiliated Hospital, Sun Yat-Sen University

Score 261 trial

Farhad Ravandi-Kashani, M.D

SWOG Cancer Research Network

📍 HOUSTON, TX

Score 257 trials2 pubs

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