Acute lymphoblastic leukemia

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At a Glance

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Regulatory Watchboard

10 events
Oct 2026HEM-iSMART E: Capivasertib + Venetoclax + Dexamethasone in Pediatric Patients With Relapsed or Refractory Hematological Malignancies

Princess Maxima Center for Pediatric Oncology — PHASE1, PHASE2

TrialNOT YET RECRUITING
Sep 2026A Study to Find the Highest Dose of SNDX-5613 (Revumenib) as a Treatment Option After Hematopoietic Stem Cell Transplant in Children With Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, and Mixed Phenotype Acute Leukemia

Children's Oncology Group — PHASE1

TrialNOT YET RECRUITING
Sep 2026This Clinical Trial is a Single-arm, Non-randomized Pilot Trial to Determine the Safety of Administering Autologous Anti-C19 Cells (ARI-0001) and the Feasibility of Local CAR-T Cell Production in Patients Over 18 Years of Age With Relapsed/Refractory (R/R) CD19+ Hematologic Malignancies, Including R

GUSTAVO SALGUERO — NA

TrialNOT YET RECRUITING
Aug 2026Clinical Performance of Giomer-Based Composite Restorations in Class V Carious Lesions in Diabetic and Non-Diabetic Patients

Cairo University — NA

TrialNOT YET RECRUITING
Jun 2026Cannabidiol as an Adjunct Treatment for Alcohol Withdrawal and Craving

Johns Hopkins University — PHASE2, PHASE3

TrialNOT YET RECRUITING
Apr 2026Hospital Based Continuous Patient Monitoring System

University of Alabama at Birmingham — NA

TrialNOT YET RECRUITING
Apr 2026Continuous Temperature Monitoring (CTM) for Cytokine Release Syndrome (CRS), an Immune-Related Adverse Event

National Cancer Institute (NCI) — NA

TrialNOT YET RECRUITING
Apr 2026CD22 CAR T-cells to Extend Remission Following Commercial CD19 CAR T-cells in Children, Adolescents, and Adults With Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia

National Cancer Institute (NCI) — PHASE2

TrialNOT YET RECRUITING
Apr 2026Etoposide, Prednisone, Vincristine, Cyclophosphamide, and Doxorubicin (DA-EPOCH) With or Without Rituximab Plus Recombinant Erwinia Asparaginase (JZP458) for the Treatment of Newly Diagnosed Ph Negative B-Acute Lymphoblastic Leukemia or T Acute Lymphoblastic Leukemia

University of Washington — PHASE2

TrialRECRUITING
Mar 2026Study to Assess the Safety, Tolerability, and Treatment Response of GXV813 in Hospitalized Adults With Schizophrenia

Novartis Pharmaceuticals — PHASE2

TrialRECRUITING

Data from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Financial Assistance

13 programs

FINANCIAL LANDSCAPE SUMMARY

13

Total programs

13

Open now

13

Copay cards

Copay Assistance13

Arranon

Novartis

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Rylaze

Jazz

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BLINCYTO

Amgen

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Marqibo

Acrotech Biopharma LLC

OpenContact for details

Oncaspar; Asparlas

Servier Pharmaceuticals LLC

OpenContact for details

Aucatzyl

Autolus Incorporated, US subsidiary of Autolus Limited

OpenContact for details

Clolar

Genzyme Corporation

OpenContact for details

Nelarabine

Novartis

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Methotrexate Sodium

Pfizer

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Xatmep

Azurity

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Erwinase

Jazz Pharmaceuticals, Inc.

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Besponsa

Pfizer

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CLOFARABINE

Sanofi

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View all support programs on disease page →

Approved Treatments

8 FDA-approved

Aucatzyl

(obecabtagene autoleucel)Orphan drug

Autolus Incorporated, US subsidiary of Autolus Limited

12.1 Mechanism of Action AUCATZYL is a CD19-directed genetically modified autologous T cell immunotherapy consisting of the patient's own T cells expr...

Approved Nov 2024FDA label ↗

Blincyto

(blinatumomab)Orphan drug

Amgen, Inc.

12.1 Mechanism of Action Blinatumomab is a bispecific CD19-directed CD3 T-cell engager that binds to CD19 expressed on the surface of cells of B-linea...

Approved Jun 2024FDA label ↗

Rylaze

(asparaginase erwinia chrysanthemi (recombinant)-rywn)Orphan drug

Jazz Pharmaceuticals Ireland Limited

Asparagine-specific Enzyme [EPC]

12.1 Mechanism of Action Asparaginase erwinia chrysanthemi (recombinant)-rywn is an enzyme that catalyzes the conversion of the amino acid L-asparagin...

Approved Jun 2021FDA label ↗

Marqibo

(vinCRIStine sulfate LIPOSOME injection)Orphan drug

Acrotech Biopharma LLC

Approved Aug 2012

Erwinase

(Erwinia L-asparaginase)Orphan drug

Jazz Pharmaceuticals, Inc.

Approved Nov 2011

Arranon

(nelarabine)Orphan drug

Novartis Pharmaceuticals Corp.

Nucleoside Metabolic Inhibitor [EPC]

12.1 Mechanism of Action Nelarabine is a prodrug of the deoxyguanosine analogue 9-β- D -arabinofuranosylguanine (ara-G), a nucleoside metabolic inhibi...

Approved Oct 2005FDA label ↗

Clolar

(clofarabine)Orphan drug

Genzyme Corporation

Nucleoside Metabolic Inhibitor [EPC]

12.1 Mechanism of Action Clofarabine is sequentially metabolized intracellularly to the 5’-monophosphate metabolite by deoxycytidine kinase and mono- ...

Approved Dec 2004FDA label ↗

Oncaspar; Asparlas

(Pegaspargase)Orphan drug

Servier Pharmaceuticals LLC

Asparagine-specific Enzyme [EPC]

12.1 Mechanism of Action L-asparaginase is an enzyme that catalyzes the conversion of the amino acid L-asparagine into aspartic acid and ammonia. The ...

Approved Feb 1994FDA label ↗

View full treatment details on disease page →

Clinical Trial Landscape

175 active trials
12Phase 3
4Phase 4
53Phase 2
35Phase 1
18N/A
15Unknown
5PHASE2, PHASE3
27PHASE1, PHASE2
6EARLY_PHASE1
175Total recruiting
Search clinical trials for Acute lymphoblastic leukemia

Recent News & Research

6 articles
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatricsApr 22, 2026

[Recent advances in individualized treatment for pediatric high-risk B-cell acute lymphoblastic leukemia].

B-cell acute lymphoblastic leukemia (B-ALL) is the most common hematologic malignancy in children. High-risk B-ALL, due to factors such as poor early treatment response and adverse genetic features, i...

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Pediatric blood & cancerApr 22, 2026

Parent Quality of Life at Two Years Following Their Child's Completion of Acute Lymphoblastic Leukemia Treatment.

Parents of children treated for acute lymphoblastic leukemia (ALL) often experience significant caregiver burden and disruption to their well-being. While parent quality of life (QoL) during treatment...

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Journal of medical virologyApr 21, 2026

Cytomegalovirus Reactivation During Therapy for Pediatric Acute Lymphoblastic Leukemia.

Cytomegalovirus (CMV) reactivation is a recognized complication after hematopoietic stem cell transplantation, but its relevance during conventional chemotherapy for pediatric acute lymphoblastic leuk...

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Discover oncologyApr 21, 2026

Investigating autophagy and miRNAs as therapeutic targets in leukemia.

Leukemia, characterized by the uncontrolled proliferation of abnormal white blood cells, encompasses several subtypes, including acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chron...

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Annals of hematologyApr 17, 2026

Identification of the Philadelphia-like subgroup in Turkish pediatric patients with acute lymphoblastic leukemia.

Ph-like ALL, a high-risk subgroup of B-cell ALL, is associated with a poor prognosis. The genetic diversity observed across different ethnicities underscores the importance of population-specific stud...

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Discover oncologyApr 15, 2026

The combination therapy with venetoclax in therapeutic strategy of acute lymphoblastic leukemia.

Acute lymphoblastic leukemia (ALL) is characterized by the malignant transformation and proliferation of lymphoid progenitor cells in the bone marrow, blood, and extramedullary sites. Leukemic cells c...

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Specialist Network

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