Acquired hemophagocytic lymphohistiocytosis associated with malignant disease

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At a Glance

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Regulatory Watchboard

10 events
May 2026Ruxolitinib for Immune Effector Cell Associated Hemophagocytic Lymphohistiocytosis-like Syndrome (RISE)

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins — PHASE1

TrialNOT YET RECRUITING
Apr 2026Comparison of Two Etoposide Initiation Strategies for Severe Hemophagocytic Lymphohistiocytosis

Assistance Publique - Hôpitaux de Paris — PHASE3

TrialNOT YET RECRUITING
Nov 2025A Phase III Clinical Study to Evaluate the Efficacy, Safety, and Tolerability of Plonmarlimab in Subjects With Relapsed/Refractory Rheumatic and Immunologic Disease-associated Haemophagocytic Lymphohistiocytosis (Also Known as Macrophage Activation Syndrome [MAS])

TJ Biopharma Co., Ltd. — PHASE3

TrialRECRUITING
Nov 2025Zanubrutinib Combined With Rituximab in the Treatment of Secondary HLH in B-cell Lymphoma

The First Affiliated Hospital of Soochow University — PHASE4

TrialRECRUITING
Oct 2025Letermovir Prophylaxis in Children With EBV-Positive T/NK-Cell Lymphoproliferative Disease and Refractory/Relapsed EBV-Associated Hemophagocytic Lymphohistiocytosis

Beijing Children's Hospital — NA

TrialRECRUITING
Aug 2025Pre-emptive Anakinra for Cytokine Event Reduction

Ann & Robert H Lurie Children's Hospital of Chicago — PHASE1, PHASE2

TrialNOT YET RECRUITING
Jun 2025Prospective Single-Arm Clinical Trial of GO Regimen for HLH.

Beijing Friendship Hospital — PHASE2, PHASE3

TrialRECRUITING
Jun 2025Dose-modified Emapalumab and Ruxolitinib (E-Ru) Regimens for Hemophagocytic Lymphohistiocytosis

The First Affiliated Hospital of Soochow University — PHASE2, PHASE3

TrialNOT YET RECRUITING
Jan 2025The Microbiome in Blood Cancer and HLH

University of Nottingham

TrialNOT YET RECRUITING
Jan 2025Safety and Efficacy of Gene Therapy of FHL Type 3 Caused by Mutations in the Human UNC13D Gene by Transplantation of a Single Dose of Autologous CD34+ Cells Transduced Ex Vivo with the UNC13D LV Vector Expressing the UNC13D CDNA

Assistance Publique - Hôpitaux de Paris — PHASE1, PHASE2

TrialNOT YET RECRUITING

Data from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Financial Assistance

FINANCIAL LANDSCAPE SUMMARY

0

Total programs

No financial assistance programs currently listed for Acquired hemophagocytic lymphohistiocytosis associated with malignant disease.
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Approved Treatments

1 FDA-approved

GAMIFANT

(EMAPALUMAB-LZSG)standard

Swedish Orphan Biovitrum AB (publ)

Interferon gamma Blocker [EPC]

12.1 Mechanism of Action Emapalumab-lzsg is a monoclonal antibody that binds to and neutralizes interferon gamma (IFNγ). Nonclinical data suggest that...

FDA label ↗

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Clinical Trial Landscape

14 active trials
1Phase 4
1Phase 2
2Phase 1
1N/A
7Unknown
1PHASE2, PHASE3
1PHASE1, PHASE2
14Total recruiting
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Recent News & Research

2 articles
BREAKINGFDA

FDA Approves GAMIFANT

GAMIFANT (EMAPALUMAB-LZSG) received FDA approval.

Read ↗
J Gastrointestin Liver DisMar 27, 2026

A Rare Case Report of Primary Hepatic Lymphoma Complicated by Hemophagocytic Lymphohistiocytosis

Published in J Gastrointestin Liver Dis. Zhang Y et al.

Read ↗

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